I used to think that the practice of “mindful meditation” was exclusively the preserve of yogis, Buddhists and New Age hippies fresh back from an extended voyage of self-discovery around Asia. If you’ve ever found yourself caught up in a conversation with an over-enthusiastic traveler fresh back from their adventures you’ll know what I mean. Such folk have usually undergone a wholesale transformation from fairly conventional individuals into barefoot, sandalwood-scented, Thai-dyed, hemp shirt and trousers wearing, bead bracelet bedecked eccentrics who preach the stupidity of capitalism and the supremacy of the compassionate mind-set at any and all available opportunities. My attitude has changed fundamentally in recent months.
A recent review paper (in Nature Reviews Neuroscience, no less) evaluating the flurry of scientific investigations into the possible benefits of practicing mindfulness that have accumulated over the past ten years or so, has given me a fresh perspective. To my surprise it turns out that there is plenty of early evidence attesting to “beneficial effects on physical and mental health; and cognitive performance.”
WHAT IS MINDFULNESS?
Mindfulness is actually a very simple concept to grasp, if only we’d give it a half chance. From the moment we wake to the moment we go back to sleep our minds are cluttered with innumerable thoughts.
These thoughts tend to focus on the past and the future: conversations, experiences and interactions that occurred in the past and hopes, ambitions, fears and other concerns regarding the future. Mindfulness encourages the development of attention directing and emotional regulating capacities that enable us to focus on the present moment. Ultimately, by getting in the habit of focusing on what we target with our conscious awareness, rather than just allowing ourselves to be buffeted by whatever stimuli, thoughts or feelings happen to flicker through our minds, we can achieve a greater self-awareness.
There are many different ways of achieving a mindful brain state but typically the beginner is encouraged to start by focusing on their breath. They are asked to breath deeply, in and out, right into the belly to ensure their diaphragm is being used to full effect. Whilst performing these simple actions they are regularly reminded to bring their attention back to their breath whenever the mind wanders elsewhere, to notice the cool air passing in through the nostrils on the inhale and the warm air passing out again on the exhale. After a few minutes of this, you are usually instructed to re-direct the focus of your attention on different body parts, moving systematically around the body. Notice the feeling of clothing on skin, upward pressure of the floor (or the chair) on your buttocks – move your mind’s eye from your toes, gradually up through the legs, into hips, up your back, across your shoulders and down your arms to your finger tips.
FOCUS AND RE-FOCUS YOUR MIND
When thoughts pop into your head, as they invariably will, the idea is not to block them or force them out, but simply to acknowledge them without engaging too deeply; focusing attention back on your breath, or touch sensations in a certain body part.
It sounds extremely simple (too straightforward to result in any meaningful benefits surely?!) but most of us are ingrained with deeply entrenched habits of thought such as worrying about events in the past or future or perpetually seeking some form of stimulation that it can take a while to achieve the goal of quiet contemplation of bodily sensations for more than 20 or 30 seconds at a time. But for those who stick at it – regularly, intensively and consistently over many weeks and months – and gradually build their ability to stay in this mindful state for 5, 15, 30, 60 mins at a time, a wide variety of benefits are achievable. And the latest neuroscience studies into mindfulness are homing in on what it going on inside the brain as a result of all this practice.
To find out about how mindfulness changes the brain please click here.
If you love science geekery then my weekly science podcast Geek Chic’s Weird Science may well be right up your alley. It’s available on iTunes, audioboom, libsyn and podbay, with the delectable Lliana Bird who presents every Fri and Sat nights on Radio X.
I also regularly share the best of the day’s neuroscience breakthroughs on Twitter so if you’d like to follow me, please click here –> @drjacklewis
In part 1 of this blog I broadly described the benefits of mindfulness and what it involves. Here I dig into the detail, outlining the parts of the brain that appear, on the basis of a recent review of many brain scanning studies, to be most consistently impacted by the regular practice of mindfulness.
NEUROPLASTICITY IN ACTION?
Using MRI scanning to focus on differences in the physical structure of brains has revealed that the anterior cingulate cortex (highlighted in yellow in the below image), often implicated in studies of attention, is physically thicker and the underlying white matter denser in practitioners of mindfulness who are highly experienced as opposed to those who are relatively inexperienced.
Moderate to severe stress is associated with high levels of circulating cortisol (a “stress” hormone). This is associated with increased density in the amygdala (highlighted in red in the below image) – a structure deep within the tips of the left and right temporal lobes and vital for orchestrating rapid responses to perceived danger. Decreased tissue density is observed within several prefrontal regions and the hippocampus – which also resides within the core of the temporal lobes – serving several memory-related functions and vital for many aspects of cognition. Regular practice of mindfulness appears to reverse this. Cognitive impairment is reduced and presumably an increase in synaptic connectivity accounts for the increase in tissue density within the hippocampal / prefrontal cortex. The enlarged amygdala shrink – presumably due to reductions in the number of synaptic connections between neurons in this region – which is also associated with a reduction in anxious feelings / the attenuation of heightened perception of threat, back down to normal levels.
The default mode network (DMN) describes a group of brain areas that are activated in MRI brain scanning studies when participants are “in between tasks”. At first these activations were thought to reflect the brain at “rest” or in “default mode.” After a few more years of research, during which this same set of activations cropped up under circumstances that couldn’t reasonably be described as “restful” the original conclusion was revised. Considering all the studies in which the DMN kicked into action it seemed much more likely that it relates instead to “mind-wandering.”
In the original studies, when the participant was instructed to “rest” they would invariably use this period to self-reflect or daydream about something completely unrelated to the experimental task (I certainly did when I volunteered for various MRI studies – it’s impossible not to – anyone that’s seen Ghostbusters should know that).
A couple of years ago when I conducted a series of interviews (British Neuroscience Conversations) with various big hitting neuroscientists at the British Neuroscience Association’s conference, neuropsychopharmacologist Prof David Nutt pointed out that, if our “ego” or the “self” lives anywhere in the brain the Default Mode Network is the best candidate.
The medial prefrontal cortex (labelled DMPFC for the dorsal/upper part and VMPFC for the ventral/lower part) and posterior cingulate cortex (PCC), i.e. the core DMN regions, were less active in experienced versus inexperienced mindfulness practitioners. As one of the primary aims of many mediation practices is to selflessly accept thoughts and feelings in a non-judgemental, compassionate way – the reduction in these neural correlates of “ego” may well reflect a degree of success in this endeavour.
So inspired have I been by these revelations of fairly solid early evidence attesting to a likely neuroplastic impact of regular practice of mindful meditation on brain areas involved in modulating attention, emotional responses and perhaps even ego that earlier in the year I went to Mykonos for a retreat to immerse myself properly (opening the invitation to anyone who faniced coming along).
Since then I’ve gone on to develop a #brainboost campaign for Weight Watchers in order to help tackle the obesity epidemic by getting people’s brains ready for healthier eating by practising mindful eating, performing a bit of daily brain training to boost their working memory and learning some simple brain hacks, all with a view to eating more strategically.
During my research for this project I came across a nice little book on mindful eating that I would highly recommend: it’s called Eating Mindfully by Susan Albers. Personally I find a lot of books on this topic extremely cringeworthy, but Susan Albers describes the practical tips on how to avoid mindless / emotional eating through mindfulness in a very straightforward manner.
My own book “Sort Your Brain Out” includes a chapter on the kind of foods and eating habits that are good and bad for the brain. In addition, I do a weekly science podcast available on iTunes, audioboom, libsyn and podbay, with the delectable Lliana Bird who presents every Fri and Sat nights on Radio X. And I regularly share the best of the day’s neuroscience breakthroughs on twitter (@drjacklewis).
A new Vodaphone advert hit our screens recently and I hate it with a passion. My gym seems to have it on a loop at the moment and every time I see it I progress through a variety of emotions ranging from mild disappointment to abject rage. It starts innocently enough, depicting a bus weaving it’s way across a patchwork quilt of luscious fields. England’s green and pleasant lands, we might assume. The driver is keeping a kindly eye on his customers through the rear view mirror, a young woman is dozing on her man’s shoulder, a suited middle-aged businessman is reading his newspaper and a teenage girl is listening to music on her headphones. One row in front of our lovers a mum finds herself unable to pacify her crying toddler. We’ve all been there. It’s not a pleasant experience when the calm and tranquility is pierced by the ululations of an irate infant child. One-by-one the cast make faces betraying their discontent over the bawling nipper. In such situations – what can you do? Other than grin and bear it?
On this particular bus, in this particular locale, a hero is at hand. In a bid to bravely defend his belle from her rude awakening, that self same man (one row behind the squalling squib) unsheathes his smartphone. And using the “Power of 4G” summons a cartoon to his screen with which to mesmerise and thus pacify the aforementioned disconsolate child. Miraculously the tears dry up immediately, the sobbing quickly replaced by smiles and giggles of joy. Peace reigns over the bus once more and glances of appreciation ensue.
The boyfriend/man/husband presumably earns himself a family-sized haul of brownie points from girlfriend having demonstrating not just a strong capacity for empathy but a clear aptitude for child wrangling (what a great dad he could be!). Mum is palpably relieved that the blight to everyone’s day has been appropriately dealt with by this marvellous stroke of genius (so embarrassing when he plays up like that!). Even the stressed out businessman seems to have gone a few shades of purple lighter. The teenage girl goes as far as taking off her headphones, momentarily, to revel in the delicious, unexpected peace and quiet before breaking into a private smile. In the estimation of these fine bus passengers, the holder of the phone is clearly nothing less than an absolute legend.
Dora the Explorer is the chosen cartoon and it’s a good choice (a much better choice than Teletubbies, for example). Inexplicably, the language she utters in this British version of the ad is Spanish. I may be showing my ignorance here. Perhaps Dora the Explorer is always aired in it’s original tongue. But it occurred to me that just maybe the ad was cheekily alluding to possibility that the kid might even start to pick up a new language as a fortuitous side effect of this timely intervention. Such is the “Power of 4G”. It’s just a shame that the evidence from several studies indicates that too much screen time spent goggling at idle entertainment displaces valuable time doing other things in the real world that really facilitate a child’s neurodevelopment. Surely encouraging the habit of endlessly distracting kids with smartphones, tablets and laptops throughout their entire childhood is only going to perpetuate this problem, not to mention fueling a boom in short-sightedness.
It’s not just Vodaphone who are at it. Nissan have also released a TV ad recently for the Pulsar. Excitingly it has automatic braking. For those unfortunate circumstances where the driver’s brain is distracted away from the road at precisely the moment the vehicle in front decides to slam on the brakes without warning. The vital milliseconds saved by circumventing the pesky human can make the critical difference between a dangerous fender bender and safely completed journey.
The key message throughout is that the car is carefully built around the driver and therefore every conceivable problem has been anticipated and addressed. In the closing scene two children appear in the back seat fidgeting, shouting and generally being… well… children. In the blink of an eye technology has magically teleported into their midst – the rowdy boys instantly transformed into well-behaved, docile and, most importantly, silent little angels: one absorbed by a tablet, the other gazing out of the window listening to something on a pair of expensive looking headphones (let’s hope it’s my podcast). That’s right kids. Do not interact with each other. That would just cause a disturbance to your father, or whoever he is. Communication must be discouraged when in ear shot of your elders and betters. And remember: silence is golden!
My issue with these ads is not Susan Greenfield-esque. I don’t believe that technology is good or bad. But I do think that to unquestioningly consume limitless hours of screen entertainment at the expense of all other activities would have negative consequences for brain development across childhood. My objection to these ads revolves around that fact that they are normalising, if not positively encouraging, child-rearing behaviours that are likely to be deleterious to the best interests of the next generation.
Study after study has demonstrated that what kids really need if their brains are to develop optimally throughout childhood is lots of interaction with other people. Ideally in the context of unstructured play. Keeping them perpetually spell-bound by computer games, films or cartoons is very much against their best interests.
Infants plonked in front of Teletubbies for hours on end are measurably retarded in their language development and verbal expression in comparison to those rarely exposed to screens in their first 2 years of life. This is ironic given that, allegedly, a large team of child psychologists were assembled by the BBC to consult on what elements should be included in order to optimise neurodevelopment.
Admittedly endless hours of interacting with young kids are shattering. And undoubtedly the most effective method of conjuring some much needed peace and quiet from the endless barrage of questions, perpetual motion, mess, mood swings and tears are screen-based innovations designed specifically to captivate young minds. But the easiest route is rarely the best path and whilst this approach may well be very convenient for frazzled parents it is demonstrably not best for the child.
Advertisers will jump on any scenario that their intended market might be able to relate to so the theme of pacifying noisy kids with tech is not surprising. Yet it supports the proliferation of lazy, unhelpful parenting tricks that ultimately work against the best interests of a whole generation of humans. Whether or not this amounts to a whole hill of beans in the long run is yet to be seen. Yet from what is known with any certainty so far, there are clear indications that screen time should be monitored and possibly limited, or else it will displace the human face-to-face interactions that so beautifully sculpt young brains in preparation for a long life of interacting with other humans.
If you want a child’s neurodevelopment to proceed optimally you should, in my humble opinion, forego the lure of using technological paraphernalia to distract them – unless you are carefully restricting its use at other times – and instead encourage them to engage in some form of play in the real world. And whilst we’re at it you should ensure that as much as possible you give them your full attention. Having your eyes on your smartphone whilst talking to your child is a terrible example to set. So much of communication happens via eye contact and active (as opposed to partially distracted) listening, so if you rob your children of valuable experience with this mode of interaction then their communication skills and social dexterity will suffer.
I’m not saying people should consign their tablets to the rubbish, nor permanently ban children from using all tech. I’m merely encouraging parents to avoid using these tactics habitually. Save it for when you really need it and you will help your kid to develop the full range of skills, both hard and soft, to give them the best possible start in life.
And if you think I’m a luddite after this rant you’d be wrong. If you explore my blog further you’ll find plenty of articles relating to the brain benefits of various computer games. Everything in moderation I say (unless we’re talking about working memory training using the Dual N-Back task or reading books in which case I see no harm in overdoing it so long as combined with a healthy social life :-))
I’ve now been on the motivational speaking circuit for over 5 years. I’ve traveled the length and breadth of the country to perform at speaking engagements in schools, science conferences and a wide variety of businesses. As of this year, on the business speaking front, I’ve been very happy to find myself in great demand not just in the U.K. but all over Europe. In light of this I thought I’d write a quick update to describe which topics have been most popular with my clients.
There is a huge amount of insight that neuroscience can provide on a wide variety of topics. It’s always satisfying to find that, in tailoring my talks to the specific needs of a client, I’m constantly stumbling upon new areas of neuroscientific endeavour with which I wasn’t previously familiar . No matter what the organisation’s priorities have been in terms of what they want their staff to take away from my talk, a few days of digging around in the neuroscience literature ALWAYS yields some inspiration; shedding an interesting new perspective on virtually any topic. Do get in touch if you have a new challenge for me!
Talks for Schools
Over the past five years I’ve been invited to speak at several different schools across the UK. The aim is to engage young learners, usually in the build up to their big exams, with an upbeat neuroscience narrative that brings to life what exactly is going on inside their brains as they learn. Once students grasp that all their efforts are leading directly to huge changes in the wiring of their brains, adaptations that support the new skills that they are developing through trial and error, their motivation levels invariably rise accordingly.
I give them insights into straight-forward techniques to get brains working better: whether memorising information more thoroughly, managing exam stress more effectively and simply encouraging them to see school as the only viable way (currently) of sculpting young brains in preparation for dealing with whatever adult life might throw at them. The 2015-2016 school year will be my fifth consecutive year of doing my Brain Coach talk at two of the schools I regularly speak at.
Talks For Business: Neuroscience of Decision Making
In the last few of years I’ve been working more and more with senior management teams across Europe to help them understand insights from neuroscience that are relevant to their specific business needs. For example, I helped one of Europe’s “Big Four” auditors win a highly lucrative new business contract by sharing with them my Neuroscience of Decision Making talk in the context of reverse engineering the pitch process in light of the flaws in how the human brain evaluates information when making important choices. By exploiting a large corpus of knowledge generated over the past decade or so from neuroeconomic investigations the realities of how risk, uncertainty and benefit are evaluated in the human brain can be explored in order to concoct strategies that improve the likelihood of developing a successful pitch.
Talks for Business: Neuroscience of Creativity
Since the first outing of my Neuroscience of Creativity talk in 2013 it has evolved into a half-day workshop experience. I’ve been rolling this Innovation Workshop out over the course of 2015 with various members of the Senior Leadership Team at one of the world’s biggest broadcasters by sharing with them everything that science has to offer in terms of techniques that work and those that sound good but ultimately don’t. By assisting them to create an environment that genuinely promotes innovative thinking right at the very top of the organisation and convincing them of the worth of approaches in an evidence-based fashion, the idea is to reduce resistance to some of the seemingly unorthodox strategies in order that they might be allowed to permeate freely throughout the rest of the company.
Sort Your Brain Out
Sadly many people proclaim that their busy lives simply leave no time to read books. So Adrian Webster and I have turned our book Sort Your Brain Out into a live event. Since our first booking late last year we have been enjoying a steady increase in demand for our motivational speaking duet over the past few months and very much hope that this trend continues in the years to come. We are both represented by Gordon Poole Agency and our speaking agent James Poole is always on hand to discuss booking enquiries.
Feeling stressed? Need a break? Fancy spending a few days in paradise to learn how to meditate?Better still would you like to learn more about how your brain works AND simple things you can do every day to be more creative, make better decisions, manage your mood?The SYBO retreats might be just the thing for you!!The venue is the beautiful Greek Island of Mykonos.Your hosts are the beautifully-bendy Jasmyn (see photos) & yours truly: the brain-besotted Dr Jack LewisWe are now offering a fantastic, luxurious, Stress-Busting, Yoga & Meditation Retreat by day with a selection of intellectually-stimulating Brain Talks just before lunch each time, freeing up the afternoons for exploration of the island’s many beaches.Meditation is clinically-proven to reduce stress. So if you’re feeling washed out after a particularly tough start to the year this really will help you to Sort Your Brain Out. It might just change your life. Jasmyn talks everyone through the various yoga moves, in a mixed group of beginners and advanced practitioners, and then concludes with a guided meditation session. These dawn and dusk sessions are complemented with several talks that explain, amongst many other things the science of meditation and why it’s so good for brains. Once a person truly grasps why mindfulness meditation is so good for health of body and brain they naturally become motivated to incorporate it into their daily routine back in the “real world.What to expect from the Neuro-Infused Art of Peaceful Living Retreats this spring / summer?The villas are in a very private neighborhood in Mykonos, Greece.The properties have 4-5 rooms each, sleeping maximum 10 per house.These neuroscience-infused Art of Peaceful Living™ programs lasts 5 days and includes:
- 21-25th May (now fully booked)
Vegetarian breakfast and lunch
Twice daily yoga and meditation practices
Either a treatment at a local day-spa or an in-room massage
All for £1,550 (€2,120) for the Spring retreat during 21st-25th May (SOLD OUT)Did I mention there is a pool?Also please bear in mind that if you want to arrive a few days early or leave a few days later we may be able to arrange accommodation for you at the villa during this time.The rooms each have a queen bed and most have private bathrooms.Every morning, as the host (Jasmyn) prepares your breakfast and lunch, she gives instruction on how to prepare these “plant-based” meals in your kitchen at home as part of the included Look Alive™ Nutrition workshops. These workshops will have recipes, and detailed explanations about why eating a plant-based is beneficial to brain-function and chemistry, physical performance, treatment of psychological disturbances and disorders, as well as a know-how to have your kitchen prepped and ready for easy to make and quick recipes.Yoga classes are all multi-level and while the morning classes can be vigorous exercise, the evening classes are relaxing and recuperative. The morning Vinyassa Yoga classes are more dynamic for beginners to advanced practitioners, and are immediately followed by a meditation class to settle the minds before the day’s activities. And of course there is no obligation to attend classes, so whether you just fancy a lie in or want to go off one afternoon for a wander, that’s totally up to you!Activities include additional excursions on the island, lounging by the on-property pool, or venturing to any of the island’s other many delights.Yoga-Nidra sessions are given at sunset following a gentle Yin-Yoga Flow class incorporating techniques of thai-massage, to restore you and prepare you for the next day’s Vinyassa Yoga sessions or for going out that night! Dinners are not usually included to give attendees freedom to roam in the evenings (unless you request to have a special dinner prepared instead of lunch).Sort Your Brain Out Retreats are 5 days of true luxury living. Treating the body and brain to wholesome, delicious food, body balancing exercise and gentle meditations, all in the privacy of the Maera Villas – with the endless view of the Mediterranean from each of the properties.Bespoke Corporate Retreats for groups of 5 or more people can also be discussed.For enquiries about availability please feel free to drop Jack an email: email@example.com
Daily brain talks from Dr Jack on:
Changing Your Brain
Neuroscience of Creativity
Neuroscience of Meditation
Neuroscience of Temptation
Do No Harm by neurosurgeon Henry Marsh is a truly magical read.
This candid, blunt and often painfully amusing collection of tales about neurosurgical procedures that went well against the odds, that went catastrophically wrong when it really should have been plain sailing, drives home how tough being a neurosurgeon really is. Several passages describe what it’s like to carefully navigate the nervous tissue packed tightly inside a person’s skull so beautifully that it verged on the poetic. Others, conveying the profound guilt associated with the realisation that an inadvertently nicked blood vessel would ultimately leave the patient permanently paralysed for the rest of their life, were so honest as to be emotionally brutalising. And as for the how the changes in the NHS have impacted on the profession of neurosurgery, not to mention the Catch 22 of how do develop surgical skills when no one wants to be operated on by a novice, it generates tremendous empathy for those brave young souls embarking from scratch on this hugely challenging career path in a totally new era.
Do No Harm really struck a chord with me on a personal level. During my teens I was always torn between a career in medicine and my scientific calling. Friends’ parents often commented that I would make a brilliant doctor and my best friend’s father, who spent most of his career as head of immunology at St Thomas’s Hospital in London, urged me on numerous occasions to take the medical route and then branch out into research later. Deep down however I lacked the courage to accept the inevitable mistakes that might lead to catastrophe for my patients. I had watched far too many episodes of the 90’s medical drama series Casualty. This excellent series may well have inspired thousands of Brits to pursue careers in medicine, but for me, it instead made me acutely aware that unnecessary deaths were an unavoidable consequence of practicing medicine. I realised that errors of judgement could spell disaster at any moment and I knew deep down that these would inevitably weigh heavily on my conscience. So I chose to pursue neuroscience instead of medicine.
The first few chapters of Do No Harm brought tears to my eyes on more than one occasion because the tales being told were not works of fiction, but instead the autobiographical real-life experiences of an extraordinarily honest man, brave enough not only to build a career in surgery but also to give equal voice to both his successes and failures.
This is an excellent book. Not only will you find it very rewarding but it might just make you realise how lucky we Brits are to have people like Henry Marsh in our beloved National Health Service.
In addition to these monthly blog postings I tweet about interesting brain-related articles in the press on a daily basis. You can follow me by clicking here.
I also do a weekly science podcast called Geek Chic’s Weird Science which you can download for free from iTunes or alternatively, if you’re not an iPhone or iPad user, you can download/stream it from a variety of online sources such as Podbay, Libsyn, and PodcastChart, amongst others!
What a year 2014 has been! On a personal level I have passed a few major career milestones (those are the firsts). So I thought I’d use my December blog post to briefly reflect upon my highlights of 2014.
My first book Sort Your Brain Out surpassed all expectations (well, mine anyway) by staying in the top ten of the W H Smith’s Travel outlet Non-Fiction Chart throughout 2014. This is despite the fact it was only ever supposed to be displayed on the Business Chart shelves.
Never in a million years did I expect my first pop at writing for the general public to sell 25,000 copies in the first nine months!! My heartfelt thanks go out to Adrian Webster (@polarbearpirate) for putting up with me as we went through the process of co-authoring together. We have already started to be booked for joint speaking engagements (to find out more, just click here) and I’m very much looking forward to spending more time in his genuinely energizing company over the coming years.
I would also like to offer huge thanks to everyone who has supported us by buying a copy and particularly those who took the time to write us a review or get in touch with us on Twitter to say how useful they found it / how much they enjoyed it. It really does make it all worthwhile to know that it is making a difference in people’s lives!
This all started in January 2014 with a regular science spot on Lliana Bird’s (@XFM_Lliana) weekly XFM radio show. Over the course of nine months spent diligently investing every Sunday morning into researching and then memorising the best of the week’s quirky science stories, by September it had evolved into a fully-fledged podcast (you can download it for free by clicking here).
Birdy and I were thrilled to find ourselves immediately rocketing towards the top of the iTunes Natural Science Podcast Chart, in the most excellent company of the likes of The Infinite Monkey Cage, The Naked Scientists, Radio Lab and various offerings from the BBC World Service and BBC Radio 4. It felt like Christmas had come early when iTunes told us that we’d made it into their “Highlights of 2014” list.
None of this would have been possible without Lliana’s determination to constantly push and experiment with different ideas (so much so that I’ve nicknamed her ‘Dynama’) and our sound producer Richard Boffin’s (@Boffintosh) diligence in finding great sound tracks, clips and effects to lift the whole production week in week out.
FIRST PRIME-TIME APPEARANCE ON BBC1
I’ve been talking neuroscience on the box since 2007. I started out on BBC2 with People Watchers, hit my first primetime audience on Sky One with How To Get What You Want and started reaching a global audience through various Discovery series such as The Tech Show. However although back in 2008 I did do a couple of experiments on the BBC1 Breakfast sofa with Bill Turnbull and company to promote the launch of People Watchers and had appeared in shows with huge viewing figures on ITV (This Morning) and Channel 4 (The Secret Life of Buildings), an appearance on a primetime BBC show has always, frustratingly, eluded me. Until now!
I’m thrilled to announce that I have finally been invited to contribute to a primetime BBC1 show. If you switch over to the “How To Save £1,000” Watchdog Special at 8pm on Thurs 15th January you will find me, early on in the programme, re-enacting the classic Walter Mischel’s Marshmellow Test with some very cute 4-year-olds and describing how this can explain difficulties that most of us encounter when trying to save money.
If you’ve ever found yourself struggling to resist the temptation of squandering cash on things you want but don’t really need then you may well find this show very interesting. Our brains don’t make it easy for us to forego immediate gratification in favour of greater rewards in the long term but it IS possible. My role in this show is to frame the basic problem. I’m led to believe that it is chock full of practical suggestions on how to circumvent it.
Wishing you all a fantastic end to 2013 and a Happy New Year.
If you’d like to follow me on Twitter please click here: @drjacklewis
If you’d like to see my latest showreel then please click here: Showreel 2014
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If you’d like to download my podcasts for free please click here: Geek Chic’s Weird Science
As 2014 draws to a close my thoughts have recently turned to pondering the greatest neuroscience discoveries of the year. For me I’ve been struck by several developments in an area of biomedical science that during most of my lifetime has been considered beyond the powers of medical therapy to provide a decent remedy.
Ever since Christopher Reeve (the actor who played Superman in the much loved films of the late 70’s and 80’s) became paralysed from the neck down during an equestrian accident in 1995, the plight of people who suffer traumatic spinal damage has seemed utterly futile; despite the huge amounts of money various benefactors have ploughed into research. However this year we have seen huge leaps in scientific advancement enabling previously wheelchair-bound people to stand up and take some small but important steps forward under their own volition.
A paralysed person kicked off the 2014 World Cup in Brazil during the opening ceremony using an EEG-controlled robotic exoskeleton. But given that the person in question had to be carried onto the pitch on a golf buggy, as opposed to rising up out of their wheelchair as promised, that feat should only really be considered a drop in the ocean compared to the much more remarkable progress in paralysis rehabilitation we’ve seen over the course of 2014.
At the beginning of the year I was invited to make an appearance on “Newsround” – the Children’s BBC channel’s daily news show – to explain a totally unexpected and extraordinary breakthrough in rehabilitation research with paralysed army veterans in the USA. A chip was surgically inserted into their spinal cord, below the sites of damage, to apply weak currents of electricity in an effort to reinvigorate the involuntary spinal reflexes that enable us to maintain our balance whilst standing (no input from the brain necessary).
This unexpected development occurred when, after a few weeks of further intensive rehabilitation exercises, several people regained voluntary movement of their legs for the first time in 2-4 years. Can you imagine how good that must have felt for the people in question? As someone who personally spent three weeks of 2014 with an almost completely paralysed arm after complication during routine surgery, it brings tears to my eyes to think how amazing it must have been to have control over legs that had previously seemed utterly useless for so many long months. It seems that the current injected by the chip had unexpectedly boosted signal strength across the area of damaged spinal cord sufficiently for the electrical messages (action potentials) to get all the way down to the leg muscles.
In 2004 whilst I was doing my PhD at University College London, I attended a talk by Prof Geoff Raisman, now chair of Neural Regeneration at the Institute of Neurology in Queen Square. He presented brand new data that he was clearly extremely excited about in which he showed data that clearly depicted new neuronal growth across the site of a spinal lesion. I cannot remember whether the experiment involved rodents or non-human primates but he made it clear that it would be many years before this pioneering research could ever be used to help paralysed humans. Today, in 2014, this dream is a reality.
Darek Fidyka was paralysed from the chest down for several years after a knife attack that severed his spinal cord. The 8mm gap that prevented messages sent from his brain to reach the muscles of his leg, penis and bladder were bridged using stem cells extracted from his brain. Mr Fidyka first underwent surgery to remove one of his two olfactory bulbs – the antennae like structures that extend forwards from the brain’s limbic system, running above each nasal cavity and extending smell receptors across the skull and into the nasal epithelium. Because the olfactory receptors come into contact with so many volatile compounds (just think of how potent the gases are that get into your nostrils when you’re downwind of a bonfire) a fair amount of damage happens to these brain cells and so they must be constantly replenished. This means that the olfactory bulbs / neurons of the nasal epithelium are a great source of stem cells.
Once sufficient numbers of Olfactory Ensheathing Cells (OECs) had been cultured and several million of them injected into the gap in his spinal cord a period of intensive rehabilitation exercises got underway. 6 hours per day 5 days per week. A few no-doubt-frustrating weeks later he graduated from walking with the assistance of parallel bars in the rehabilitation gym, to walking with a frame outside the hospital in Wroclaw, Poland where the surgery took place. Perhaps as important he regained some bladder control and sexual function. An incredible achievement for Mr Fidyka, but an absolutely triumph for Prof Raisman and the hundreds of people that have contributed to the groundwork that led to this unbelievable feat of brilliance.
This story was covered in episode 10 of the podcast Geek Chic’s Weird Science – co-presented by yours truly and the gorgeous Lliana Bird – which you can subscribe to on iTunes, absolutely free of charge, by clicking here.
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As a neuroscientist who spends much of his working life giving brain talks at events all around the country (at schools, conferences and science festivals) I’ve noticed that one theme catches public imagination over and over again: How does caffeine work? What does it do to my brain? How long does it stay in my system? Is it really that bad for me? This is one reason why it became one of the key topics in the “Smart” Drugs chapter of my book: Sort Your Brain Out. In this blog I’ll cover some of the most regularly asked questions.
How long caffeine takes to leave your system?
It depends what other drugs you’re on. If you’re on the contraceptive pill it can take up to twice as long for your liver to remove caffeine from your system. So people “on the pill” can find themselves particularly sensitive to its effects because consecutive doses stack up and are not cleared out as swiftly as in everyone else. But if you’re a smoker it is the other way around. Caffeine is removed from your system at double the speed of a non-smoker.
If you’re neither a smoker nor on the contraceptive pill the concentration of caffeine in your bloodstream is halved every 5-6 hours, but it really does depend on the individual as this “half-life” varies greatly from person-to-person.
Is it beneficial to have caffeine before a meeting / presentation / to improve concentration?
Caffeine blocks the receptors of an inhibitory neurotransmitter called adenosine, which under normal circumstances reduces overall activity across the brain. By blocking these receptors and removing the dampening influence on brain activity, caffeine increases activity across brain pathways involved in alertness, focusing attention and initiating body movements. This why people dosed up on caffeine can get quite jittery.
Whether or not caffeine is beneficial for you in a meeting / presentation or to improve concentration whilst working depends on how much you’ve already had. There’s a sweet spot where you will feel more alert and switched on at moderate levels, but beyond that you can become so wound up that it has effects that are deleterious to performance (see description of caffeinism below).
However the increase in feelings of alertness and ability to focus attention only gets regular coffee drinkers up to levels enjoyed by non-caffeine drinkers everyday. This is because once you’re a caffeine addict the brain tends to increase the numbers of adenosine receptors to compensate for the fact that there’s loads of caffeine swimming around in your brain on a daily basis. This means that your average coffee drinker has more inhibitory receptors in their brain dampening activity levels to a greater degree – so they will feel more sluggish whenever they don’t have caffeine in their system.
Is caffeine good or bad for you in the long run?
There seem to be some long-term benefits to drinking caffeine even if the short-term benefits don’t amount to a whole hill of (coffee) beans. It has been observed that regular drinkers of moderate amounts of caffeine (3 cups / day) have a lower incidence of Parkinson’s, Alzheimer’s, liver and heart diseases. This may be due to the increased numbers of inhibitory receptors triggered by ever-present levels of caffeine dampening activity levels in body and brain. The decreased activity levels across the brain caused by the larger numbers of inhibitory receptors in the caffeine drinkers’ brains may relieve the pressure on dopamine neurons that are compromised in Parkinson’s disease and the acetyl choline neurons that get clogged up with various proteins in Alzheimer’s disease. In other words caffeine seems to slow down the process of cell death so that symptoms of these diseases kick in several years later than in your average non-caffeine drinker. At the moment this mechanism is purely speculative. The jury’s still out on the precise mechanism that might account for these observations, but the evidence supporting the concept of moderate amounts of caffeine having a neuroprotective influence on the brain is steadily increasing.
Is it important to control and monitor your caffeine intake?
A dose of 10g is deadly – 100 cups and a human may well find themselves popping their clogs as a typical cup of brewed coffee contains 100mg of caffeine. (NB you may notice that in the above video from the lovely people at ASAPscience they say 1 cup of coffee has 150mg – presumably they brew it stronger over in Canada For the non-coffee drinkers out there here are some average caffeine contents of some other popular drinks. There are 80mg in a can of Red Bull, 75mg in a cup of instant coffee, 50mg in a cup of tea, 30mg in a can of Coca Cola.
Very high but not deadly doses can lead to a quite severe psychiatric condition known as caffeinism: “which is characterised by restlessness, agitation, excitement, rambling thought and speech, and insomnia.” (Winston et al, 2005). It is important to control and monitor caffeine intake because too much can interfere with appetite, make people anxious or depressed, not to mention the fact that anything that interferes with sleep will have a deleterious effect on the brain. Everyone’s sensitivity to caffeine is slightly different, but if you have trouble sleeping then you’d be well advised to avoid caffeine at least 5-6 hours before bedtime – for your brain’s sake.
3 cups of coffee per day is considered a “moderate dose” for most people. Get these in early enough to avoid any potential for them to interfere with sleep and you should get the apparent long-term brain benefits without the negative consequences associated with excessive consumption (DISCLAIMER: this should not be interpreted as medical advice – it is just the science-based opinion of the author who has a Ph.D. in neurobiology i.e. not a medical degree!).
I don’t like tea or coffee, are there any other sources of caffeine?
Caffeine is also found in kola nut (one of the original ingredients of coca cola) and guarana – a wonder berry from the Brazilian rainforest; it’s also found in low quantities in chocolate. Caffeine is also included as a stimulant in many cold and flu remedies – so beware what you reach for when you wake up in the middle of the night with a bunged up nose!
By the way: if you study the picture on the left very carefully you’ll find a face amongst the coffee beans – can you find it?
Keep looking… he’s definitely there and you’ll kick yourself for doubting me when you find him!!
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Parks and open spaces improve health and quality of life by incentivising people to get out and take some exercise, which is extremely good for brain health. Just being within eye shot of some greenery can accelerate healing – so even if you can’t get outside, all you need is a room with a view! If it wasn’t for the armies of parkies and council cleaning staff who clean up after members of the public who routinely leave their litter behind, these green spaces would soon become the last place you would want to spend your spare time. The question is: why do people leave their litter behind for somebody else to clear up in the first place?
All human behaviours are governed, more-or-less, by the brain’s predictions of reward and punishment. We are subconsciously guided towards actions that maximise rewards whilst minimising punishments. The pleasure pathways of the brain, in particular the nucleus accumbens, are involved in attaching a reward prediction to a certain course of action based on past experience. Drinking water when thirsty or eating food when hungry are examples of behaviours hardwired to produce powerful sensations of pleasure because they help to keep us alive. However the sense of pleasure that people get from putting rubbish in the bin is not innate, like drinking and eating, but instead it must be learned.
Nonetheless, even in the absence of a sense of reward from putting rubbish in the bin, if littering is consistently punished then that too can steer people away from anti-social and towards pro-social behaviours. Whilst most parents are still apt to discipline their children for littering, which provides valuable experience of the punishments that follow such anti-social behaviour, parents aren’t always around. In the past adults felt at liberty to scold, or even physically punish, any child that they happened to see dropping litter, but in the modern climate of political correctness this has become a thing of the past. Young people no longer learn that punishment reliably follows the act of dropping litter and so their brains do not generate the sense of discomfort, anxiety or unease (generated, if you’re interested, by the anterior insula) that would precede acts of anti-social behaviour that they know through experience is likely to be punished. So in the absence of any negative emotions associated with the act of littering, nor positive emotions associated with the act of putting litter in the bin, rubbish ends up being lobbed around willy nilly, even when a bin is conveniently located just a few steps away.
When children are brought up with a strong sense of social responsibility then in later life they may get sensations of what might be called “righteous” pleasure from doing the “right thing.” The point is that to get a feeling of satisfaction from performing pro-social behaviours you must have been trained over prolonged periods of time by parents, carers, teachers and/or peers in order to get a kick out of it. If society wants to encourage pro-social behaviours we’ve either got to praise young people more for putting litter in the bin, or make them very uncomfortable when they just drop it for someone else to deal with. Or, take a leaf out of the Texan’s book. They had great success in reducing littering on the highway (after many years of failure with several different approaches) by adopting a campaign that would appeal to young men’s sense of pride and bravado (see left).
A fascinating study, again from the journal Science (Keizer et al, 2008), indicates that evidence of other people’s antisocial behaviour can make others more likely to be antisocial themselves. This would suggest that the problem with litter goes beyond just rubbish on the streets and in our parks. In one of their experiments they demonstrated that environments in which anti-social behaviour was evident, e.g. litter strewn around on the pavement, graffitti sprayed on the walls or fire crackers set off in the background, not only makes people more likely to litter themselves, but also to commit more serious anti-social behaviours like theft. It seems that people modulate their own behaviour according to cues regarding the degree of anti-social behaviours committed by others. So if you really want to stop other people dropping litter, you might consider reducing the evidence of other people’s anti-social behaviour by picking it up yourself!
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