• The Iceman Cometh by Dr Jack

    Have you ever heard of the Iceman? He is a remarkable Dutchman who has developed what seems like genuine superpowers. His many accomplishments include hiking up Mount Kilimanjaro wearing just hiking boots and shorts, swimming underwater for over 50m in a frozen Finnish lake and running a marathon 200m north of the Arctic Circle. However the most impressive thing about this particular real-life superhuman is that far from claiming to be unique, instead he boasts that anyone can do it. In the process of taking steps to prove this to the doubters he has brought the Wim Hoff method under scientific scrutiny which has led directly to an amazing discovery – we really can control our immune systems!!

    IMG_7430I choose to write about this now because on 1st Jan 2016 I had to shrug off my hangover to fly to Amsterdam. On the 2nd Jan 2016 I met up with a Professor of Immunology to discuss the latest published scientific studies on the Iceman and his disciples designed to test and ultimately explain the mechanisms though which their impressive abilities to withstand the pain of freezing cold temperatures might be achieved. Then on the morning of 3rd Jan 2016 I finally met Wim Hoff and by midday, after just an hour’s training, I was neck deep in a cold lake in the middle of the Dutch countryside with 300 enthusiasts. Life can be strange sometimes.

    What I learned over the course of these few illuminating days in the Netherlands at the beginning of the month is that the Wim Hoff technique essentially involves three key processes: hyperventilation, cold immersion and a meditative mind state. Better still, each stage actually feeds into the next in a scientifically plausible manner.

    Hyperventilation – what is it good for?

    When we think of hyperventilation most people focus on the fact that it will saturate the blood with oxygen thus enabling more energy to be released when performing some kind of physically or mentally demanding task. Of course by breathing in and out, deeply and rapidly, for prolonged periods of time (in my case 3 sets of 30 full inhalation/exhalation cycles) as well as increasing oxygen input it will also eliminate more of the major waste material of metabolism that is carbon dioxide. And this, it turns out, is the most important part of the equation when it comes to withstanding environmental temperatures that would usually be deemed to be painfully cold.

    When carbon dioxide is dissolved in your blood it forms a weakly acidic solution called carbonic acid. So the more carbon dioxide in your blood the more acidic it is. Conversely by removing more and more of this carbon dioxide from solution you can consciously exert control over your blood’s pH by making it increasingly alkaline. In fact, it turns out that a pro like Wim can shift his blood pH from 7.2 right up to a more alkaline 7.85. Now that might not sound like a huge difference, but bearing in mind that on a scale that runs from 1 (extremely acidic) to 14 (extremely alkaline) this make 7.2 more or less bang on neutral and 7.85 is getting into the realms of weakly alkaline.


    Alkaline blood – so what?

    So what happens if you make your blood weakly alkaline through a few bouts of hyperventilation. I’ll give you a clue, why would women in the process of giving birth to a child instinctively hyperventilate? Pain relief. You see what Wim stumbled upon as he was experimenting with different techniques to try and find the peace of mind he sought during the years after his wife died in 1995 leaving him to raise 4 children single-handedly was that by making your blood every so slightly alkaline you render pain receptors inoperable.

    There is a special “trimer” protein inside your skin’s nociceptors – the specialised receptors embedded in your skin that send electrical messages to the brain that end up being perceived as painful whenever a potentially damaging stimulus (like extreme cold) is detected in the environment. Trimers are so-called because they are formed from three separate strings of amino acids that wrap around each other to form a complex structure with a very specific function – signalling pain. But in the presence of slightly alkaline blood these three parts separate rendering the pain receptors unable to send any signals. Therefore the invigorating cold can be experienced in the absence of an associated perception of pain! So simple, but so clever.

    How Cold Immersion begets a Meditative State

    As I discovered on that cool day in early January, once you’ve got your blood alkalinity up through hyperventilation you can immerse yourself in cold water without feeling any pain. You do feel the cold, just with the aversive component of this experience switched off. And it was this experience of cold without pain that helped Wim to focus his mind not on the horrors of the past, not on the worrying aspects of the future, but to be centred entirely on the present. The exhilarating feeling of having the cold pressing in from all sides whilst in a state of undress. Getting into a meditative state through cold immersion was the only technique that reliably helped him to stay “in the moment” sufficiently to achieve the peace of mind he was looking for.

    IMG_7427Wim Hoff is a lively character. Sitting still in peace and quiet is simply not his style. He is almost perpetually in motion. Any spare moment he will take the opportunity to do some chin ups, balance his body on his elbow like some kind of breakdance fiend or simply do the splits. And this is a part of the overall process of becoming the Iceman. In addition to the cytokines released in response to regular cold exposure, Wim’s body is also thought to release myokines – messenger proteins released from active muscles. The combination of these influences means that his DNA is being read differently from the rest of us more sedentary modern humans.

    Hyper Life versus the Easy Life

    It’s almost as if Wim has managed to trick his body into reverting to caveman mode. There is scientific evidence to support the hypothesis that after decades of leading a hyperactive, hyperventilated life including daily exposure to extreme conditions, every single one of his cells has started to read off a different set of genes to the rest of us. I’ve never met anyone with more energy, yet he doesn’t eat breakfast or lunch, just one (presumably huge) meal in the early evening, which is probably how our ancient ancestors dined having spent the whole day hunting and foraging for the evening meal. We modern men and women on the other hand spend our days ensconced in centrally heated / air conditioned homes and workplaces, spending the vast proportion of our days sedentary with packed fridges just a few steps away and so our bodies switch on genes that adequately support this easy life.

    A New Perspective

    IMG_7429Many diseases that used to kill off our ancestors in huge numbers are now firmly under control thanks to the marvels of modern medicine. Of those which still place our lives and quality of life in peril, several involve and element of over-activity in our immune systems; so-called autoimmune diseases like rheumatoid arthritis and multiple sclerosis, to name but few. Wim’s brave auto-experimentation, combined with his profound desire to bring his discoveries firmly under the scrutiny of science have enabled the revelation that he has incredible control over his immune system. He (and volunteers who have followed his approach under clinical conditions) can bring down the levels of pro-inflammatory IL-6 and IL-8, whilst boosting levels of anti-inflammatory IL-10 to the point where he doesn’t get sick when exposed to bacterial endotoxins. Whilst control subjects respond to the toxic injection by shivering feverishly within about half an hour, the Iceman sits there unperturbed by the nasties in his bloodstream. The potential to learn his technique in order to reduce overactive immune systems and thereby defeating various autoimmune diseases is bringing hope to many whom had previously lost faith in prospect of a cure.

    In addition to these monthly brain blogs, you can follow me on Twitter (@drjacklewis) for daily updates on breakthroughs in neuroscience, buy my first book Sort Your Brain Out at all good bookshops and see me back on your TV’s very soon in two brand new series on insight.tv and Red Bull TV!


    Read more »
  • Review: High Society at the Wellcome Trust Collection by Dr Jack Lewis

    Henry Solomon Wellcome was well ahead of the game when it came to the “Mo-vember” look for a charitable soul

    With just one week to go before it closes (Sun 27th Feb 2011) I visited the “High Society” exhibition at the Wellcome Collection in London yesterday so that I could review it here in case you were curious.

    I would like to state for the record that I LOVE THE WELLCOME TRUST and would rate Henry Wellcome in my top 5 heroes of all time. His enormously generous philanthropic endowment has turned into a fantastic instution built on sound priniciples that have withstood the tests of time.

    Not only does the WT fund an enormous amount of British scientific research (my PhD included – during which my scientific approach was gradually sculpted under the influence of many extraordinary neuroscientists; most of whom were also Wellcome Trust funded), but it also takes it’s role in public engagement with science, a subject very close to my heart, extremely seriously.

    This commitment to spreading the good word of scientific innovation old and new is, I believe, deliciously exemplified by the special exhibitions that rotate through their space on the Euston Road a few times per year to showcase an interesting area of scientific enquiry. These exhibitions beautifully complement the tone set by the permanent collection upstairs: ancient medical tools, scientific relics and other treasures from the history of medicine; not to mention some outstanding fashion photography modelled by good old Henry himself.

    In late 2010/early 2011 the show space addressed the issue of mind-altering substances. From the outset the visitor couldn’t help but be impressed upon that these chemicals have been popping up throughout history everywhere, for millenia. Drugs of various description have been consumed in one form or another across ALL cultures of the world. And the vehicle for explaining this was a lovely collection of drug paraphernalia from all over the globe and a whole bunch of amazing facts about the drug trade both medical, illicit and sometimes both.

    Psilocybin is a hallucinogenic substance found in certain species of mushrooms

    The free exhibition included a 6th century BC embossed tablets from the Middle East describing some of the medical uses of Cannabis sativa, ornately decorated tobacco pipes, ancient betel nut cutters, indian and chinese opium pipes right up to the modern day DIY crackpipe (comprising a small water bottle, a biro casing and some perforated tin foil).

    These drug taking curiosities, collected from all corners of the earth, may well have encouraged spectators to consider why human beings everywhere are so keen to experiment with mind-stimulating (or mind-depressing) substances in spite of the potential dangers, for instance, picking the wrong mushroom and popping your clogs.

    People expecting an exhilarating experience may have been disappointed. I personally believe it is always important to arrive at an event free of the burden of overly-high expectations. And it worked just fine for me as there were some real treasures within.

    Shockingly heroin was once sold by Bayer pharmaceuticals as an everyday medicine

    Highlights for me included some of the black and white footage documenting Andean Indians drinking the potently hallucinogenic ayahuasca extract (which immediately makes a person vomit and is deemed to be a good thing… helping to purify body and soul prior to entry into the “other” world) provided a fanastic account of how, why and where these indigenous tribespeople enter into this ritual.

    Also the footage of a 1950’s experiment in which a “terribly posh” doctor tests a volunteer before and after consumption of the hallucinogenic drug mescaline. I thought it was very amusing that he was considerably better at counting down from 100 to zero in blocks of 7 (i.e. 100, 93, 86, 79 etc) when he was tripping compared to before he had taken any drug. Also amusing (to me at least) was the way he answered all questions from the battery of cognitive tests directly in a very authoritative manner, yet failed absolutely to find suitable words to describe the gorgous array colours that were hallucinogenically tinting his vision and no doubt also inducing his huge grin.

    Scandalous: when our plentiful supplies of silver and gold were no longer worth what they were the British Empire got China hooked on opium so that we could trade that instead!

    It was also very interesting to get an insight into some of the details of the Opium Wars in which the British used Afghani opium to get the whole of East Asia hooked on smack as a solution to plummeting gold and silver prices leaving them with no barganing chips with which to trade. An absolute scandal of which I had no prior knowledge. There was also an ingenious installation involving various projectors and light filters beaming amorphous colours and shapes onto a large screen that I could have watched for hours – very relaxing.

    The sillhouettes are spectators standing in front of the projectors, not part of the trippy art installation – or are they?

    And on the way out I found the large graphical representations of the relative yearly global turnover elicited from trading legal versus illegal drugs of recreation very interesting – as the relative size of the cannabis versus cocaine versus opiate markets are not as you might expect, particularly when compared to the computer game or pornography markets. Another large graph that effortlessly conveyed a lot of information in a very straightforward, user-friendly manner depicted the gradually declining purity and increasing costs of cocaine as goes from being picked and processed at source, moved from Andean regions to the Carribean, imported into the UK and then sold to the end consumer. It seems that the biggest jump in the cost per kilo occurs, not surprisingly if you think about it, when it enters the country in which it is to be sold, the suprise comes when it is revealed that the hike in cost from before to after is a whopping 600%.

    This ball of opium is the size of my fist!!

    In conclusion it was an eye-opening and fascinating excursion into the world of illicit drugs through the ages showing how our interest in them across all cultures has always been there and will probably always remain.

    Remember you can follow Dr Jack to catch his daily #braintweets.

    Read more »